The most common cancers were lung, colorectal, stomach, breast, and pancreas, and the most common metastases were in the liver, lymph nodes, and bone.ĭrugs used for palliative sedation included neuroleptics (used in 84.2% of patients) such as chlorpromazine, promethazine, and haloperidol, benzodiazepines (54.3%) such as lorazepam, midazolam, and diazepam, and opioids (25.5%) such as morphine. nutrition therapy after initiation of sedation as evidence of physician intent to hasten patient death.12,16-20,22. Palliative sedation is effective for reducing the suffering of terminally ill cancer patients without hastening death. Mean survival after the initiation of continuous palliative sedation is reported to be one to six days. In addition, there were no statistically significant differences in the location of the primary tumor or metastases. Various publications show that continuous palliative sedation that is correctly administered to patients with a very short prognosis does not hasten death. nasia.9-12 In addition, use of palliative sedation does not hasten death when conducted in accordance with stan- dard guidelines.13-15. Patients in the 2 cohorts were matched for age, sex, Karnofsky performance status, reason for hospice admission, and predicted survival. Kirk, PhD, chair of the Palliative Sedation. The overall prevalence of palliative sedation therapy in the patients who were admitted to these hospices was 25.1%, with very little variability among the centers ( +5%). One of the primary misunderstandings about palliative sedation is that it hastens death, according to Timothy W. J Palliative sedation therapy used for the control of refractory symptoms in cancer patients with very advanced disease does not hasten death, a new prospective study concludes. show that, in populations of patients undergoing palliative care, sedation does not have a negative impact on survival and that the doctrine of double effect is. Maltoni and colleagues recruited 518 patients from 4 hospices in the Emilia-Romagna region of Italy. Excess sedation can theoretically cause an increased risk of aspiration pneumonia and respiratory suppression.
As such, the pros and cons of palliative sedation should be clearly outlined to the patient/family to manage expectations.
#Does palliative sedation hasten death trial#
This latest trial is the first - as far as the authors are aware - that prospectively matched sedated patients with nonsedated patients in such a way that the 2 cohorts differed only in terms of 1 characteristic (ie, sedation).ĭr. The use of palliative sedation continues to be a controversial topic, given that its use can potentially hasten death.
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